Table 1.

Substrates of ADAMs in the kidneys

ADAMs	Substrates	Roles in kidney development and disease	References
ADAM10	Notch	Involved in metanephric development; determined the cell fate of the collecting ducts; promoted podocyte and mesangial cell maturation; aggravated renal fibrosis	[16, [19], [20], [21], 60]
	CXCL16	Promoted mesangial cells proliferation and migration; mediated inflammation factors production and podocyte migration; recruited of T cells to the kidney	[41, 45, 46]
	KIM-1	Modulated the phagocytic process	[57]
	E-cadherin	Involved in kidney fibrosis	[59]
	Meprin A	Induced inflammation and matrix remodulation	[56]
ADAM17	EGFR ligands (HB-EGF and TGFα)	Promoted proinflammatory factors upregulation and inflammatory cell infiltration; promoted profibrotic factors release and induced interstitial fibrosis; induced glomerular matrix accumulation leading to glomerulosclerosis	[31], [32], [33], [34], [35]
	ACE2	Induced albuminuria; mediated the shedding of TCEs	[74]
	Notch	Involved in glomerular development	[30]
	CXCL16	Promoted mesangial cells proliferation and migration; mediated inflammation factors production and podocyte migration	[41, 45]
	Nox4	Enhanced oxidative stress; induced matrix accumulation	[32]
	TNFα	Promoted inflammation and fibrosis	[33]
	EPCR	Promoted glomerular endothelium damage	[68]