TABLE 4.

Predictors of Progression-Free Survival (n = 429)

Predictors	Univariate	Multivariate
Margin tumor prescription dose ≥12 Gy (vs <12 Gy)	HR = 0.306 95% CI [0.140-0.670], P = .003	HR = 0.310 95% CI [0.141-0.679], P = .003a
BED ≥60 Gy (vs <60 Gy)	HR = 0.291 95% CI [0.135-0.624], P = .002	HR = 0.310 95% CI [0.141-0.679], P = .003a
Single-fraction SRS (vs hypofractionated)	HR = 0.148 95% CI [0.032-0.692], P = .048	HR = 0.078 95% CI [0.016-0.395], P = .002
Maximal tumor dose (Gy)	HR = 0.909 95% CI [0.842-0.981], P = .015	P = .076
Dose to optic apparatus (Gy)	P = .231	–
Distance to optic apparatus (mm)	P = .755	–
Tumor volume (cm3)	P = .854	–
Pre-SRS radiation therapy	HR = 11.222, 95% CI [1.1430-88.060], P = .021	P = .063
Pre-SRS surgery	P = .371	–
Pre-SRS visual deficit	HR = 2.560 [1.087-6.028], P = .031	P = .133
Age (yr)	P = .741	–
Gender	P = .793	–

SD, standard deviation.

^a– seprate multivariate Cox regression models adjusted for signifficant predictors in univariate analyses.