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. Author manuscript; available in PMC: 2021 Oct 15.
Published in final edited form as: Nat Genet. 2020 Sep 14;52(10):1036–1045. doi: 10.1038/s41588-020-0684-4

Fig. 5 |. Drug target prioritization (priority index, Pi) score of our drug target candidates.

Fig. 5 |

The red lines indicate the Pi rating of our drug target candidates for the respective diseases (listed in Supplementary Table 8A,B). The gray violin plots indicate the distribution of the Pi rating, for the respective diseases, of all the genes for which a Pi rating has been computed (number of genes indicated in parenthesis). The gray lines indicate the 90th and the 95th percentiles of the Pi rating values. IgD, HLA, CD45RA and CD3 have been excluded because the Pi rating was not available. Gene aliases: TNFRSF13C (BAFF-R), ITGAM (CD11b), ITGAX (CD11c), IL3RA (CD123), MS4A1 (CD20), IL2RA (CD25), PTPRC (CD45), SELL (CD62L), FCGR1A (CD64), CD8A (CD8), TNFRSF14 (HVEM), FCGR2A (CD32). The acronyms are as in Fig. 3; ATD, autoimmune thyroiditis; ALG, allergy; ASM, asthma. The boxplot inside the violin plot reports a circle indicating the median value, with the box limits indicating the upper and the lower quartiles. The whisker at the upper side of the box extends to the minimum between the interquartile range × 1.5 and the overall maximum value of the data. The whisker at the bottom side of the box extends to the maximum between the interquartile range × 1.5 and the overall minimum value of the data.