TABLE 1.

The codon composition of all genes related in the lenvatinib antitumor pathway.

Gene	Total codon count	ANN codon count	ANN codon ratio (%)	Rank	Gene	Total codon count	ANN codon count	ANN codon ratio (%)	Rank
KRAS	189	68	35.98	1	PI3K	1,660	438	26.39	37
BRCA1	1793	616	34.36	2	FasL	282	73	25.89	38
NRAS	190	62	32.63	3	FOX O 3	674	174	25.82	39
PTPRR	413	134	32.45	4	HRAS	190	49	25.79	40
PTEN	404	131	32.43	5	Grb2	218	56	25.69	41
RASGRF1	1,182	377	31.90	6	FGFR1	823	211	25.64	42
KIT	977	307	31.42	7	PDK1	557	142	25.49	43
sap1a	406	127	31.28	8	MYC	440	112	25.45	44
RAPGEF2	1,487	463	31.14	9	MYC	440	112	25.45	45
RAF1	649	200	30.82	10	MNK1	425	108	25.41	46
c-myb	450	138	30.67	11	EGF	1,153	291	25.24	47
GPCR	434	133	30.65	12	ERK1	380	95	25.00	48
MDM2	196	60	30.61	13	BCL-xl	234	58	24.79	49
RASGRF2	1,238	378	30.53	14	IRS1	1,243	308	24.78	50
RASGRF2	1,238	378	30.53	15	CCND1	296	73	24.66	51
MAPT	384	117	30.47	16	c-fos	381	93	24.41	52
CDK7	347	105	30.26	17	ARAF	610	148	24.26	53
PP2A	468	141	30.13	18	VEGFR3-s	1,299	313	24.10	54
PKC	707	213	30.13	19	VEGFR3-l	1,364	325	23.83	55
SRF	509	152	29.86	20	GSK3A	484	115	23.76	56
ERK2	361	107	29.64	21	DUSP1	368	86	23.37	57
MEK1	394	116	29.44	22	RASGRP2	610	139	22.79	58
RASGRP3	691	203	29.38	23	IKK	488	111	22.75	59
CDK9	373	109	29.22	24	CASP9	417	94	22.54	60
FGFR2	705	206	29.22	25	CREB	462	104	22.51	61
CDK8	465	135	29.03	26	HSP90AA1	733	248	33.83	62
EGFR	1,092	314	28.75	27	Elk1	429	92	21.45	63
VEGF	164	47	28.66	28	BAD	169	35	20.71	64
RASGRP	798	228	28.57	29	RASGRP4	674	137	20.33	65
RASGRP1	798	228	28.57	30	FGFR3	807	164	20.32	66
GSK3B	421	118	28.03	31	NOS3	1,204	242	20.10	67
CDK10	43	12	27.91	32	FGFR4	763	147	19.27	68
NFKB1	969	260	26.83	33	BCL2	240	46	19.17	69
MEK2	401	107	26.68	34	RET	459	84	18.30	70
TP53	215	57	26.51	35	p21	165	27	16.36	71
BRAF	767	203	26.47	36	p27	130	18	13.85	72

^aThe average level of ANN ratio in all genes is 26.16%.