TABLE 1.
Gene | Total codon count | ANN codon count | ANN codon ratio (%) | Rank | Gene | Total codon count | ANN codon count | ANN codon ratio (%) | Rank |
---|---|---|---|---|---|---|---|---|---|
KRAS | 189 | 68 | 35.98 | 1 | PI3K | 1,660 | 438 | 26.39 | 37 |
BRCA1 | 1793 | 616 | 34.36 | 2 | FasL | 282 | 73 | 25.89 | 38 |
NRAS | 190 | 62 | 32.63 | 3 | FOX O 3 | 674 | 174 | 25.82 | 39 |
PTPRR | 413 | 134 | 32.45 | 4 | HRAS | 190 | 49 | 25.79 | 40 |
PTEN | 404 | 131 | 32.43 | 5 | Grb2 | 218 | 56 | 25.69 | 41 |
RASGRF1 | 1,182 | 377 | 31.90 | 6 | FGFR1 | 823 | 211 | 25.64 | 42 |
KIT | 977 | 307 | 31.42 | 7 | PDK1 | 557 | 142 | 25.49 | 43 |
sap1a | 406 | 127 | 31.28 | 8 | MYC | 440 | 112 | 25.45 | 44 |
RAPGEF2 | 1,487 | 463 | 31.14 | 9 | MYC | 440 | 112 | 25.45 | 45 |
RAF1 | 649 | 200 | 30.82 | 10 | MNK1 | 425 | 108 | 25.41 | 46 |
c-myb | 450 | 138 | 30.67 | 11 | EGF | 1,153 | 291 | 25.24 | 47 |
GPCR | 434 | 133 | 30.65 | 12 | ERK1 | 380 | 95 | 25.00 | 48 |
MDM2 | 196 | 60 | 30.61 | 13 | BCL-xl | 234 | 58 | 24.79 | 49 |
RASGRF2 | 1,238 | 378 | 30.53 | 14 | IRS1 | 1,243 | 308 | 24.78 | 50 |
RASGRF2 | 1,238 | 378 | 30.53 | 15 | CCND1 | 296 | 73 | 24.66 | 51 |
MAPT | 384 | 117 | 30.47 | 16 | c-fos | 381 | 93 | 24.41 | 52 |
CDK7 | 347 | 105 | 30.26 | 17 | ARAF | 610 | 148 | 24.26 | 53 |
PP2A | 468 | 141 | 30.13 | 18 | VEGFR3-s | 1,299 | 313 | 24.10 | 54 |
PKC | 707 | 213 | 30.13 | 19 | VEGFR3-l | 1,364 | 325 | 23.83 | 55 |
SRF | 509 | 152 | 29.86 | 20 | GSK3A | 484 | 115 | 23.76 | 56 |
ERK2 | 361 | 107 | 29.64 | 21 | DUSP1 | 368 | 86 | 23.37 | 57 |
MEK1 | 394 | 116 | 29.44 | 22 | RASGRP2 | 610 | 139 | 22.79 | 58 |
RASGRP3 | 691 | 203 | 29.38 | 23 | IKK | 488 | 111 | 22.75 | 59 |
CDK9 | 373 | 109 | 29.22 | 24 | CASP9 | 417 | 94 | 22.54 | 60 |
FGFR2 | 705 | 206 | 29.22 | 25 | CREB | 462 | 104 | 22.51 | 61 |
CDK8 | 465 | 135 | 29.03 | 26 | HSP90AA1 | 733 | 248 | 33.83 | 62 |
EGFR | 1,092 | 314 | 28.75 | 27 | Elk1 | 429 | 92 | 21.45 | 63 |
VEGF | 164 | 47 | 28.66 | 28 | BAD | 169 | 35 | 20.71 | 64 |
RASGRP | 798 | 228 | 28.57 | 29 | RASGRP4 | 674 | 137 | 20.33 | 65 |
RASGRP1 | 798 | 228 | 28.57 | 30 | FGFR3 | 807 | 164 | 20.32 | 66 |
GSK3B | 421 | 118 | 28.03 | 31 | NOS3 | 1,204 | 242 | 20.10 | 67 |
CDK10 | 43 | 12 | 27.91 | 32 | FGFR4 | 763 | 147 | 19.27 | 68 |
NFKB1 | 969 | 260 | 26.83 | 33 | BCL2 | 240 | 46 | 19.17 | 69 |
MEK2 | 401 | 107 | 26.68 | 34 | RET | 459 | 84 | 18.30 | 70 |
TP53 | 215 | 57 | 26.51 | 35 | p21 | 165 | 27 | 16.36 | 71 |
BRAF | 767 | 203 | 26.47 | 36 | p27 | 130 | 18 | 13.85 | 72 |
The average level of ANN ratio in all genes is 26.16%.