Figure 6.

Initial reaction velocities, V_obs, for the Diels–Alder cycloaddition of sorbic alcohol (6.00 mM), and maleimide (6.00 mM), catalyzed by ^C11R₆ (1.34 mM, 22 mol %) in CDCl₃ under ambient conditions (25 °C). Reaction velocity was measured by the depletion of maleimide (δ = 6.72 ppm) referenced to a TMS standard by ¹H NMR. Reaction water content spanned 11.77–34.87 mM (8.76–25.95 molecules per capsule) as determined by Karl–Fischer titration. The water content was used to estimate ^C11R₆-B conversion by an empirical model (eq S1). Error bars correspond to the standard error in the linear fitting of the initial reaction velocity (Figure S6). A linear fit (red) reveals the turnover frequency of ^C11R₆-A (0.24 ± 0.06 h^–1) and ^C11R₆-B (2.16 ± 0.29 h^–1).