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. 2021 Sep 13;12(22):6610–6619. doi: 10.7150/jca.58500

Figure 2.

Figure 2

FIN56 induces ferroptosis in GBM cells. (A) Images of BODIPY581/591 C11 staining of LN229 and U118 cells treated with 1 μM FIN56 or DMSO (control) for 24 h. (B) Images of immunofluorescence staining of 4-HNE of LN229 and U118 cells treated with 1 μM FIN56 or DMSO (control). (C) Images of CellRox green staining of LN229 and U118 cells treated with 1 μM FIN56 or DMSO (control). (D) Ultrastructure of LN229 cells treated with 1 μM FIN56 or DMSO (control) by transmission electron microscopy. Mitochondria were pointed out in DMSO (black arrows) and FIN56 (red arrows) treatment group. **P < 0.01; ***P < 0.001. Size bars in (A), (B) and (C): 10 µm, in (D): 0.5 µm.