Skip to main content
. 2021 Sep 13;12(22):6610–6619. doi: 10.7150/jca.58500

Figure 3.

Figure 3

FIN56 causes lysosomal membrane permeabilization in a ferroptosis-dependent manner. (A) Fluorescence images of acridine orange staining of LN229 and U118 cells treated with 1 μM FIN56 or DMSO (control). (B) Fluorescence images of EGFP-Gal3 transfection of LN229 and U118 cells treated with 1 μM FIN56 or DMSO (control). (C) Quantification of green puncta in (B). (D) Fluorescence images of EGFP-Gal3 transfection of LN229 and U118 cells treated with DMSO (control), 1 μM FIN56 or, 2 µM ferrostatin-1 (Fer-1) or 2 µM ferrostatin-1 (Fer-1) combined with 1 μM FIN56. (E) Quantification of green puncta in (D). **P < 0.01; scale bars: 10 µm.