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. 2021 Sep 23;12(22):6787–6795. doi: 10.7150/jca.62352

Figure 2.

Figure 2

miRNAs regulate the function of ER stress in digestive cancer. (1) miR199a/214 targets XBP-1 to induce apoptosis in liver cancer; miR-3091-3p targets Atg9b to enhance ER stress induced apoptosis in liver cancer; miR-663 targets FGFB1 to inhibit ER stress induced apoptosis in liver cancer; miR221/222 promotes ER stress induced apoptosis in liver cancer; (2) miR370 targets HERPUD1 to promote survival pathway of ER stress in gastric cancer; miR-379-5p targets GRP78 to inhibit survival pathway of ER stress in gastric cancer; miR-143 targets ORP8 to inhibit ER stress and downstream pathway to inhibit apoptosis in gastric cancer; miR-133a-3p enhances ER stress induced apoptosis in gastric cancer; (3) miR-451 targets BAP31 thus inhibit ER stress induced apoptosis in colorectal cancer; miR-7112-3p targets PERK to inhibit ER stress induced apoptosis in colorectal cancer; miR-103a-3p inhibits pro-apoptosis function of ER stress.