Figure 1.

Both ABT-199 and metformin inhibited growth of AML cells and the combined treatment has a synergetic effect. (A-C) The IC₅₀ of ABT-199 in KG-1 (A), Kasumi-1 (B) and THP-1 cells (C) for 24, 48 hours. (D-F) The IC₅₀ of metformin in KG-1 (D), Kasumi-1 (E) and THP-1 cells (F) for 48 hours. (G) The inhibition ratio of ABT-199, metformin and their combination in THP-1 cells when the concentration of ABT-199 was fixed at 0.064 µM (left) and 0.08 µM (right). (H) The concentration of ABT-199 was fixed at 0.064 µM (left) and 0.09 µM (right), the inhibition ratio of different concentrations of metformin and the combination of the two drugs in KG-1. (I) The inhibition ratio of ABT-199, metformin and the combination in Kasumi-1 cells when the concentration of ABT-199 was fixed at 0.032 μM(left) and 0.064 µM (right) (*P < 0.05; ** P < 0.01; *** P < 0.001). (J) The bliss index of ABT-199 fixed at 0.064 µM (left) and 0.08 µM (right) in THP-1. (K) The bliss index of ABT-199 fixed at 0.064 µM (left) and 0.09 µM (right) in KG-1. (L) The bliss index of of ABT-199 fixed at 0.032 µM (left) and 0.064 µM (right) in Kasumi-1.