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. 2021 Sep 21;12(22):6727–6739. doi: 10.7150/jca.60208

Figure 2.

Figure 2

ABT-199 and metformin co-treatment has a synergistic pro-apoptosis effect on AML cells. THP-1 (A), KG-1 (D) and Kasumi-1 (G) were treated with ABT-199, metformin, or ABT-199/metformin for 48 hours, the fraction of apoptotic cells was analyzed by Annexin V/PI staining and flow cytometric analysis. The statistical result of the (A), (D) and (G) graph results were shown in (B), (E) and (H) (*P < 0.05; ** P < 0.01; *** P < 0.001). The apoptosis protein PARP (c-PARP) was examined by western blot in THP-1 (C), KG-1 (F) and Kasumi-1 (I).