Figure 5. Egocentric bearing cells participate in context reinstatement during spatial memory recall.

(A) Hypothesis on the cognitive processes during memory cues: object recognition (supported by object cells) may trigger pattern completion (involving the activity of conjunctive object by egocentric bearing cells) and context reinstatement (associated with EBC activity). Planning of navigation routes may follow. (B) Firing rates of object cells during cue presentation of trials with the preferred object(s) vs. trials with unpreferred object(s). (C) Firing rates of conjunctive object by egocentric bearing cells during cue presentation of trials with their preferred object(s) as compared to object cells that are not EBCs. (D) Firing rates of conjunctive object by egocentric bearing cells during cue presentation of trials with the unpreferred object(s) as compared to object cells that are not EBCs. (E) Illustration of the separation of cue periods into “close” and “far” depending on whether the location of the cueing object is close to or farther away from the reference point, respectively. (F) Firing rates of EBCs during cue presentation of trials in which the object location is close to the reference point vs. trials in which the object location is farther away from the reference point. Shaded areas, SEM across cells. P-values result from cluster-based permutation tests, which control for multiple comparisons across the entire time windows; black shading at top, time points from the significant cluster. Firing rates in B, C, D, and F are baseline-corrected with respect to a one-second baseline interval before the onset of the cue period.