Table 1.

Selected observed of Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) values for the synthesized cyclopentenones.^[a]

CP	Sa		MRSA		Ef		VRE		Ec		Sc		HEK 293T
	MIC [μg ⋅ mL−1]	MBC [μg ⋅ mL−1]	MIC [μg ⋅ mL−1]	MBC [μg ⋅ mL−1]	MIC [μg ⋅ mL−1]	MBC [μg ⋅ mL−1]	MIC [μg ⋅ mL−1]	MBC [μg ⋅ mL−1]	MIC [μg ⋅ mL−1]	MBC [μg ⋅ mL−1]	MIC [μg ⋅ mL−1]	MFC [μg ⋅ mL−1]	[% viability at 20 μM]
6	7.81	>31.2	15.6	250	1.95	>15.6	7.81	>62.5	62.5	125	62.5	125	90
7	7.81	>62.5	3.91	>31.2	1.95	>15.6	3.91	>31.2	62.5	250	31.2	62.5	95
8	3.91	>31.2	3.91	>31.2	0.49	>3.91	0.98	15.6	62.5	250	62.5	125	65
9	7.81	250	62.5	250	15.6	500	nt	nt	nt	nt	31.2	125	59
20	7.81	>62.5	0.976	>7.81	0.976	>7.81	3.91	62.5	62.5	125	15.6	62.5	100
Vanco	1.95	500	3.91	nt	<0.49	>500	62.5	>500
NOR									<0.49	500
NYS											15.6	500

[a] The MIC corresponding to the lowest concentration at which no visible growth was observed, was assessed by the microdilution method. For MBC evaluation, the bacterial suspension on the wells was homogenized, serial‐diluted, triplicate spread on appropriate medium and incubated at 37 °C for 24 h. Data represent the median values of at least three replicates. Vanco: vancomycin. NOR: norfloxacin. NYS: nystatin. Sa: Staphylococcus aureus. MRSA: methicillin‐resistant Staphylococcus aureus. Ef: Enterococcus faecalis. VRE: vancomycin‐resistant Enterococcus faecalis. Ec: Escherichia coli. Sc: Saccharomyces cerevisiae. HEK: Human Embryonic Kidney.