TABLE 6.
Health outcomes in patients with hemophilia over 50 years old
| <50 (N = 613) | 50+, overall (N = 388) | 50+, severe hemophilia (N = 115) | 50+, non‐severe hemophilia (N = 273) | |
|---|---|---|---|---|
| Median annual bleeding rate | 613 | 388 | 115 | 273 |
| Rate (IQR) | 1 (0–228) | 0 (0–100) | 3 (0–100) | 0 (0–100) |
| Missing | 109 | 45 | 14 | 31 |
| Median annual joint bleeding rate | 613 | 388 | 115 | 273 |
| Rate (IQR) | 0 (0–70) | 0 (0–70) | 2 (0–70) | 0 (0–25) |
| Missing | 95 | 44 | 14 | 30 |
| Hospital admissions (%) | 613 | 388 | 115 | 273 |
| No | 419 (82) | 261 (72) | 86 (77) | 175 (69) |
| Yes | 93 (18) | 103 (28) | 26 (23) | 77 (31) |
| Missing | 101 | 24 | 3 | 21 |
| d Duration of hospital stay in days | 66 | 83 | 25 | 58 |
| Median (range) | 5 (1–80) | 6 (1–175) | 7 (1–125) | 5 (1–175) |
| Missing | 5 | 2 | 0 | 2 |
| Joint impairment (%) | 613 | 388 | 115 | 273 |
| Some impairment | 123 (25) | 153 (47) | 96 (96) | 57 (25) |
| No impairment | 376 (75) | 175 (53) | 4 (4) | 171 (75) |
| Missing | 114 | 60 | 15 | 45 |
| Orthopedic surgery in the past, any type (%) | 613 | 388 | 115 | 273 |
| No | 280 (82) | 219 (60) | 28 (25) | 191 (76) |
| Yes | 63 (18) | 145 (40) | 84 (75) | 61 (24) |
| Missing | 270 | 24 | 3 | 21 |
| Orthopedic surgery in the past, joint replacement surgery (%) | 343 | 364 | 112 | 252 |
| No | 325 (95) | 274 (75) | 46 (41) | 228 (90) |
| Yes | 18 (5) | 90 (25) | 66 (59) | 24 (10) |
| Orthopedic surgery in the past, arthrodesis (%) | 343 | 364 | 112 | 252 |
| No | 327 (95) | 311 (85) | 72 (64) | 239 (95) |
| Yes | 16 (5) | 53 (15) | 40 (36) | 13 (5) |
| Orthopedic surgery in the past, synovectomy (%) | 343 | 364 | 112 | 252 |
| No | 334 (97) | 346 (95) | 100 (89) | 246 (98) |
| Yes | 9 (3) | 18 (5) | 12 (11) | 6 (2) |
| Number of orthopedic interventions | 343 | 364 | 112 | 252 |
| Mean (SD) | 0.4 (0.9) | 0.9 (1.4) | 1.9 (1.5) | 0.5 (1.1) |
| Missing | 2 | 4 | 1 | 3 |
| c HIV status (%) | 136 | 280 | 108 | 172 |
| Negative | 126 (93%) | 264 (95%) | 95 (88%) | 169 (100%) |
| Positive | 9 (7%) | 13 (5%) | 13 (12%) | 0 (0%) |
| Missing | 1 | 3 | 0 | 3 |
| a HCV status (%) | 198 | 298 | 108 | 190 |
| Always HCV‐negative | 85 (51) | 93 (38) | 3 (3) | 90 (62) |
| Past infection | 80 (48) | 146 (60) | 92 (93) | 54 (37) |
| Current infection | 2 (1) | 6 (2) | 4 (4) | 2 (1) |
| Missing | 31 | 53 | 9 | 44 |
| HCV treatment among HCV‐positive patients (%) | 82 | 152 | 96 | 56 |
| No | 12 (15) | 23 (15) | 11 (12) | 12 (22) |
| Yes | 67 (85) | 126 (85) | 83 (88) | 43 (78) |
| Missing | 3 | 3 | 2 | 1 |
| Last treatment (%) | 167 | 126 | 83 | 43 |
| DAA | 15 (28) | 28 (25) | 19 (26) | 9 (24) |
| DAA +RBV | 2 (4) | 24 (21) | 13 (18) | 11 (29) |
| DAA +RBV + PEG‐IFN | 3 (6) | 5 (4) | 4 (5) | 1 (3) |
| PEG‐IFN +RBV | 19 (35) | 24 (21) | 16 (22) | 8 (21) |
| IFN +RBV | 11 (20) | 21 (19) | 13 (18) | 8 (21) |
| IFN | 4 (7) | 10 (9) | 9 (12) | 1 (3) |
| Missing | 13 | 14 | 19 | 5 |
| b Liver fibrosis/cirrhosis (%) | 82 | 152 | 96 | 56 |
| No significant fibrosis (<9.5 kPa) | 32 (91) | 56 (75) | 37 (76) | 19 (73) |
| Significant fibrosis (9.5 −12.4 kPa) | 1 (3) | 7 (9) | 4 (8) | 3 (12) |
| Cirrhosis (>12.4 kPa) | 2 (6) | 12 (16) | 8 (16) | 4 (15) |
| Missing | 47 | 77 | 47 | 30 |
Abbreviations: DAA, direct acting antivirals; HCV, hepatitis C virus; HIV, human immunodeficiency virus; IFN, interferon; PEG‐IFN, pegylated‐interferon; RBV, ribavirin; SD, standard deviation.
a
Reported for 298 patients >50 years treated with coagulation factor before 1992.
b
Based on FibroScan measurements.
c
Reported for 280 patients >50 years treated with coagulation factor before 1985.
d
Reported for patients that stayed at least one night in the hospital (day admissions were excluded).