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. 2021 Oct 15;19:322. doi: 10.1186/s12951-021-01062-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — Multifunctional activities of Rg3-PTX-liposomes in vivo. A Rg3 substituting cholesterol are utilized to fabricate Rg3-PTX-liposomes. The liposomes recognize GLUT of BBB through the glycosyl moiety of Rg3 and are easier to penetrate to brain across the BBB. B Rg3-PTX-liposomes targeting to TAM induce the transformation of M2 into M1, thus stimulating tumor immunotherapy. C Rg3-PTX-liposomes induce apoptosis of tumor cells. D Rg3-PTX-liposomes promote the differentiation of T cells into CD4⁺ and CD8⁺T cells. Reprinted with the permission from Ref [28].

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