Table 1.
Demographic and anthropometric characteristics of study participants according to ABSI-by-HI body-shape phenotypes
| MEN | WOMEN | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall | Pear | Slim | Wide | Apple | P | Overall | Pear | Slim | Wide | Apple | P | |
| Cancer risk dataset | ||||||||||||
| Cohort size: n (%) | 200,289 | 47,515 (23.7) | 56,606 (28.3) | 58,621 (29.3) | 37,547 (18.7) | 230,326 | 55,366 (24.0) | 49,149 (21.3) | 70,934 (30.8) | 54,877 (23.8) | ||
| Colon cancer cases: n (%) | 1029 | 171 (16.6) | 238 (23.1) | 362 (35.2) | 258 (25.1) | 889 | 174 (19.6) | 164 (18.4) | 303 (34.1) | 248 (27.9) | ||
| Follow-up time (years) | 6.9 (1.4) | 7.0 (1.3) | 6.9 (1.3) | 6.9 (1.5) | 6.8 (1.5) | < 0.001 | 7.0 (1.3) | 7.1 (1.2) | 7.0 (1.2) | 7.0 (1.3) | 6.9 (1.3) | < 0.001 |
| Age at enrolment (years) | 57.2 (8.1) | 55.6 (8.4) | 55.5 (8.1) | 59.2 (7.6) | 58.8 (7.5) | < 0.001 | 56.8 (8.0) | 55.5 (8.1) | 55.2 (8.0) | 58.2 (7.7) | 57.8 (7.7) | < 0.001 |
| A Body Shape Index (ABSI) | 79.8 (4.1) | 77.1 (2.3) | 76.3 (2.7) | 83.3 (2.5) | 83.0 (2.4) | < 0.001 | 73.8 (5.0) | 69.7 (2.4) | 69.3 (2.8) | 77.4 (3.5) | 77.3 (3.3) | < 0.001 |
| Hip Index (HI) | 49.1 (1.7) | 50.2 (1.0) | 47.6 (1.1) | 50.4 (1.2) | 47.9 (1.0) | < 0.001 | 64.2 (2.5) | 65.9 (1.5) | 62.1 (1.7) | 66.0 (1.6) | 62.2 (1.5) | < 0.001 |
| Waist-to-Hip Index (WHI) | 4.08 (0.22) | 3.85 (0.14) | 4.02 (0.16) | 4.15 (0.15) | 4.35 (0.16) | < 0.001 | 3.59 (0.27) | 3.31 (0.14) | 3.50 (0.16) | 3.66 (0.18) | 3.87 (0.20) | < 0.001 |
| Body Mass Index (BMI) (kg/m2) | 27.8 (4.0) | 27.4 (4.2) | 27.7 (3.7) | 27.9 (4.4) | 28.3 (3.9) | < 0.001 | 26.9 (4.8) | 26.2 (4.8) | 26.3 (4.4) | 27.5 (5.2) | 27.5 (4.4) | < 0.001 |
| NW: ≥18.5 to < 25 kg/m2: n (%) | 49,992 (25.0) | 14,286 (30.1) | 13,219 (23.4) | 15,222 (26.0) | 7265 (19.3) | < 0.001 | 92,272 (40.1) | 26,765 (48.3) | 22,218 (45.2) | 26,258 (37.0) | 17,031 (31.0) | < 0.001 |
| OW: ≥25 to < 30 kg/m2: n (%) | 99,591 (49.7) | 22,667 (47.7) | 29,911 (52.8) | 27,650 (47.2) | 19,363 (51.6) | 85,748 (37.2) | 18,461 (33.3) | 18,380 (37.4) | 24,930 (35.1) | 23,977 (43.7) | ||
| OB: ≥30 to < 45 kg/m2: n (%) | 50,706 (25.3) | 10,562 (22.2) | 13,476 (23.8) | 15,749 (26.9) | 10,919 (29.1) | 52,306 (22.7) | 10,140 (18.3) | 8551 (17.4) | 19,746 (27.8) | 13,869 (25.3) | ||
| DXA dataset | ||||||||||||
| Cohort size: n (%) | 15,520 | 2515 (16.2) | 6951 (44.8) | 3060 (19.7) | 2994 (19.3) | 16,548 | 3175 (19.2) | 4408 (26.6) | 4590 (27.7) | 4375 (26.4) | ||
| Time from enrolment (years) | 8.7 (1.8) | 8.4 (1.8) | 8.6 (1.8) | 8.8 (1.7) | 9.2 (1.6) | < 0.001 | 8.7 (1.7) | 8.4 (1.8) | 8.6 (1.8) | 8.9 (1.6) | 8.8 (1.8) | < 0.001 |
| Age at imaging (years) | 63.9 (7.1) | 63.1 (7.3) | 62.6 (7.1) | 66.1 (6.5) | 65.4 (6.7) | < 0.001 | 62.9 (7.0) | 62.3 (7.0) | 61.5 (7.1) | 64.3 (6.8) | 63.4 (6.8) | < 0.001 |
| A Body Shape Index (ABSI) | 78.9 (4.2) | 76.9 (2.4) | 76.0 (2.8) | 83.3 (2.6) | 82.7 (2.3) | < 0.001 | 73.8 (5.2) | 69.6 (2.6) | 69.1 (2.8) | 77.9 (3.9) | 77.3 (3.3) | < 0.001 |
| Hip Index (HI) | 48.3 (1.9) | 50.1 (0.9) | 47.1 (1.3) | 50.4 (1.3) | 47.6 (1.1) | < 0.001 | 63.8 (2.6) | 65.8 (1.5) | 61.7 (1.7) | 66.1 (1.6) | 62.0 (1.6) | < 0.001 |
| Waist-to-Hip Index (WHI) | 4.09 (0.22) | 3.85 (0.14) | 4.04 (0.17) | 4.14 (0.15) | 4.36 (0.16) | < 0.001 | 3.62 (0.27) | 3.31 (0.15) | 3.51 (0.16) | 3.69 (0.20) | 3.90 (0.20) | < 0.001 |
| Body Mass Index (BMI) (kg/m2) | 27.1 (3.9) | 27.0 (4.2) | 27.0 (3.6) | 27.2 (4.3) | 27.4 (3.9) | < 0.001 | 26.2 (4.5) | 25.9 (4.7) | 25.5 (4.1) | 26.6 (4.9) | 26.5 (4.2) | < 0.001 |
| NW: ≥18.5 to < 25 kg/m2: n (%) | 4958 (31.9) | 872 (34.7) | 2206 (31.7) | 1031 (33.7) | 849 (28.4) | < 0.001 | 7759 (46.9) | 1662 (52.3) | 2311 (52.4) | 2024 (44.1) | 1762 (40.3) | < 0.001 |
| OW: ≥25 to < 30 kg/m2: n (%) | 7501 (48.3) | 1163 (46.2) | 3467 (49.9) | 1369 (44.7) | 1502 (50.2) | 5824 (35.2) | 956 (30.1) | 1495 (33.9) | 1549 (33.7) | 1824 (41.7) | ||
| OB: ≥30 to < 45 kg/m2: n (%) | 3061 (19.7) | 480 (19.1) | 1278 (18.4) | 660 (21.6) | 643 (21.5) | 2965 (17.9) | 557 (17.5) | 602 (13.7) | 1017 (22.2) | 789 (18.0) | ||
| MRI dataset | ||||||||||||
| Cohort size: n (%) | 3997 | 886 (22.2) | 1857 (46.5) | 780 (19.5) | 474 (11.9) | 4402 | 1077 (24.5) | 1253 (28.5) | 1007 (22.9) | 1065 (24.2) | ||
| Time from enrolment (years) | 6.6 (1.0) | 6.6 (1.1) | 6.6 (1.0) | 6.7 (1.0) | 6.6 (1.0) | 0.058 | 6.7 (1.0) | 6.7 (1.0) | 6.6 (1.0) | 6.7 (1.0) | 6.7 (1.1) | 0.012 |
| Age at imaging (years) | 62.8 (7.4) | 62.2 (7.5) | 61.4 (7.5) | 65.7 (6.5) | 64.9 (6.3) | < 0.001 | 61.7 (7.2) | 61.3 (7.1) | 60.4 (7.4) | 63.3 (6.9) | 62.1 (7.0) | < 0.001 |
| A Body Shape Index (ABSI) | 78.1 (3.9) | 76.8 (2.4) | 75.8 (2.8) | 82.6 (2.2) | 82.2 (2.1) | < 0.001 | 72.9 (4.6) | 69.5 (2.6) | 69.5 (2.5) | 76.7 (3.0) | 76.7 (3.1) | < 0.001 |
| Hip Index (HI) | 48.6 (1.7) | 50.1 (1.0) | 47.4 (1.1) | 50.4 (1.1) | 47.8 (1.0) | < 0.001 | 63.8 (2.4) | 65.9 (1.5) | 61.9 (1.6) | 65.8 (1.4) | 62.1 (1.5) | < 0.001 |
| Waist-to-Hip Index (WHI) | 4.03 (0.2) | 3.85 (0.14) | 4.01 (0.16) | 4.11 (0.12) | 4.31 (0.14) | < 0.001 | 3.58 (0.26) | 3.31 (0.15) | 3.51 (0.15) | 3.64 (0.16) | 3.86 (0.18) | < 0.001 |
| Body Mass Index (BMI) (kg/m2) | 27.1 (3.8) | 27.1 (4.0) | 27.3 (3.6) | 26.8 (4.1) | 27.0 (3.6) | 0.013 | 26.2 (4.5) | 25.7 (4.6) | 25.8 (4.2) | 26.8 (5.0) | 26.5 (4.0) | < 0.001 |
| NW: ≥18.5 to < 25 kg/m2: n (%) | 1235 (30.9) | 297 (33.5) | 503 (27.1) | 289 (37.1) | 146 (30.8) | < 0.001 | 2055 (46.7) | 563 (52.3) | 635 (50.7) | 422 (41.9) | 435 (40.8) | < 0.001 |
| OW: ≥25 to < 30 kg/m2: n (%) | 1975 (49.4) | 405 (45.7) | 986 (53.1) | 341 (43.7) | 243 (51.3) | 1555 (35.3) | 335 (31.1) | 427 (34.1) | 343 (34.1) | 450 (42.3) | ||
| OB: ≥30 to < 45 kg/m2: n (%) | 787 (19.7) | 184 (20.8) | 368 (19.8) | 150 (19.2) | 85 (17.9) | 792 (18.0) | 179 (16.6) | 191 (15.2) | 242 (24.0) | 180 (16.9) | ||
ABSI a body shape index (cut-offs: ≥80 for men; ≥73 for women); Apple large-ABSI-small-HI; DXA dual-emission X-ray absorptiometry; HI hip index (cut-offs: ≥49 for men; ≥64 for women); MRI magnetic resonance imaging; n (%) number of participants (percentage from the total per column or, for cohort size and cancer cases, percentage from total per sex); NW normal weight; OB obese; OW overweight; P p-values from one-way ANOVA (continuous variables) or chi-squared test (categorical variables) comparing the four body-shape phenotypes per sex; Pear small-ABSI-large-HI; Slim small-ABSI-small-HI; Wide large-ABSI-large-HI. Continuous variables are summarised with mean (standard deviation)