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. 2021 Oct 14;14:136. doi: 10.1186/s13048-021-00888-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ_0061140 silencing repressed the PTX resistance and development of ovarian cancer. (A) The knockdown efficiency of circ_0061140 and circ_0061140 was detected by qRT-PCR in PTX-resistant SKOV3 and HeyA8 cells. (B and C) The effects of circ_0061140 silencing on cell viability after PTX exposure (0.1, 0.5, 1, 5, 10, 50 and 100 nM) were determined by MTT assay in PTX-resistant SKOV3 and HeyA8 cells. (D-F) The impact of circ_0061140 knockdown on cell proliferation was revealed by CCK-8 and colony formation assays in PTX-resistant SKOV3 and HeyA8 cells. (G) Flow cytometry analysis was performed to unveil the impact of circ_0061140 silencing on the apoptosis of PTX-resistant SKOV3 and HeyA8 cells. (H and I) The influences of circ_0061140 absence on the migration and invasion of PTX-resistant SKOV3 and HeyA8 cells were investigated by transwell assay. *P < 0.05