Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 14;14:136. doi: 10.1186/s13048-021-00888-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — Circ_0061140 regulated the progression and PTX sensitivity of ovarian cancer by sponging miR-136. (A and B) The impacts between circ_0061140 knockdown and miR-136 depletion on cell viability after PTX treatment were revealed by MTT assay in PTX-resistant SKOV3 and HeyA8 cells. (C-E) The influences between circ_0061140 knockdown and miR-136 silencing on the proliferation of PTX-resistant SKOV3 and HeyA8 cells were explained by CCK-8 and colony formation assays. (F) Flow cytometry analysis was carried out to investigate the effects between circ_0061140 knockdown and miR-136 downregulation on the apoptosis of PTX-resistant SKOV3 and HeyA8 cells. (G and H) Transwell assay was performed to investigate the influences between circ_0061140 silencing and miR-136 RNAi on cell migration and invasion in PTX-resistant SKOV3 and HeyA8 cells. *P < 0.05