Fig. 16.

Perivascular microglia in the brain of blast-exposed animals. Panels a–c show clustered Iba 1⁺ microglia (red, arrow in b) with amoeboid morphology in the perivascular area of a tortuous large vessel (pericallosal artery) in the corpus callosum of a rat brain at 13 months post-blast exposure. Panel d shows an orthogonal projection of a section through a thalamic artery stained for perivascular astrocytes (GFAP⁺, green) and microglia (Iba1⁺, red). Co-localization of astrocytic GFAP⁺ material within a perivascular microglial cell, suggests phagocytic ingestion of perivascular astrocytes by microglia. Scale bar, 100 µm a; 40 µm b; 20 µm c, d