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. 2021 Oct 15;23:259. doi: 10.1186/s13075-021-02633-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SSc-Cont differences for the serum proteins are significantly associated with SSc-Cont differences in skin. a SSc-Cont differences are positively correlated between serum proteins and corresponding skin transcripts. b WAP score ranks of differentially expressed serum proteins for SSc-Cont differences in skin and in PBC (lower values of rank represent more significant WAPs). c Ratios of observed to expected counts of pathway network connections between differentially expressed serum proteins and top 50, 100, and 250 most differentially expressed transcripts in SSc vs. Cont comparisons in skin (cyan) and in PBC (pink) and corresponding edge-count probabilities. Horizontal dashes (green) in c represent unremarkable case of the count of observed edges being equal to that expected for randomly rewired pathway network under null model of random graph with given expected degrees