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. 2021 Oct 14;13:107. doi: 10.1186/s13098-021-00725-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CDKN2B-AS1 acted as a sponge for miR-98-5p. A The binding sites between CDKN2B-AS1 and miR-98-5p were predicted by the starBase database. B, C Dual-luciferase reporter assay was executed for the assessment of the luciferase reporter with WT-CDKN2B-AS1 or MUT-CDKN2B-AS1 in HPCs and HK-2 cells transfected with miR-98-5p mimic or miRNA NC. D The expression of miR-98-5p in HPCs and HK-2 cells transfected with miR-98-5p inhibitor or inhibitor NC was detected via qRT-PCR. E, F Impact of miR-98-5p inhibitor on the expression of miR-98-5p in CDKN2B-AS1-inhibiting HPCs and HK-2 cells was analyzed through qRT-PCR. G, H The expression of miR-98-5p in serum of DN patients and high glucose-treated HPCs and HK-2 cells was determined via qRT-PCR. *P < 0.05