TABLE 2.

Meta‐analysis results of donor loci associated with postoperative thrombotic events

SNP	CHR	POS	Effect allele	Other allele	MAF	Meta OR	Meta p value	Q	Pediatric cohort (n = 310)			Adult cohort (n = 775)
									OR	SE	p value	OR	SE	p value
rs35150895	4	67445833	A	G	0.05	3.45	6.28E−07	0.29	4.92	0.42	1.39E−04	2.84	0.31	7.22E−04
rs7784948	7	124069511	T	G	0.09	2.58	1.55E−06	0.99	2.59	0.33	4.50E−03	2.58	0.24	1.07E−04
rs72935945	6	110655675	T	C	0.19	2.23	3.21E−06	0.99	2.23	0.29	4.97E−03	2.24	0.22	2.03E−04
rs9998058	4	169596553	C	T	0.07	2.71	6.14E−06	0.56	3.25	0.38	2.15E−03	2.48	0.27	7.50E−04
rs10421769	19	33605312	C	T	0.33	0.42	6.32E−06	0.30	0.32	0.33	4.92E−04	0.49	0.24	2.28E−03
rs3849111	9	111994722	A	C	0.37	0.43	6.53E−06	0.33	0.54	0.29	3.04E−02	0.37	0.24	4.64E−05
rs56222681	6	156478953	A	G	0.14	2.30	8.82E−06	0.59	2.64	0.31	1.81E−03	2.13	0.24	1.32E−03
rs1965492	15	76773326	C	A	0.42	1.98	8.89E−06	0.76	1.87	0.24	1.01E−02	2.05	0.20	2.77E−04
rs56076602	21	42051160	G	C	0.08	2.78	9.18E−06	0.10	4.57	0.38	5.66E−05	2.07	0.29	1.25E−02
rs10049756	4	28872833	A	G	0.12	2.27	1.01E−05	0.95	2.24	0.30	6.60E−03	2.29	0.24	4.97E−04
rs2818388	10	133953647	A	C	0.07	2.67	1.17E−05	0.49	2.19	0.36	3.09E−02	3.01	0.28	1.06E−04
rs34979186	8	28445552	G	A	0.06	2.90	1.33E−05	0.76	3.21	0.40	3.95E−03	2.74	0.31	1.04E−03
rs72789970	2	37970145	G	A	0.05	2.92	1.37E−05	0.92	2.82	0.42	1.40E−02	2.97	0.30	3.31E−04
rs1288906	5	103023993	T	A	0.16	2.16	1.50E−05	0.56	1.86	0.31	4.57E−02	2.32	0.22	1.03E−04
rs9951171	18	9749879	A	G	0.41	0.48	1.76E−05	0.86	0.47	0.27	5.21E−03	0.50	0.22	1.10E−03
rs73179545	3	176238294	C	T	0.08	2.70	1.90E−05	0.39	3.60	0.41	1.71E−03	2.35	0.28	2.44E−03
rs1566159	8	104090278	A	T	0.36	0.47	2.04E−05	0.73	0.44	0.28	2.91E−03	0.50	0.23	2.16E−03
rs10904015	10	3327415	G	A	0.22	2.01	2.08E−05	0.74	1.86	0.27	2.36E−02	2.09	0.20	2.94E−04
rs59286975	10	64736664	A	G	0.07	2.70	2.15E−05	0.96	2.66	0.41	1.80E−02	2.72	0.28	4.15E−04
rs2827676	21	24030707	T	C	0.13	2.25	2.15E−05	0.57	1.93	0.33	4.35E−02	2.43	0.24	1.56E−04
rs9957543	18	31659307	G	C	0.42	0.48	2.21E−05	0.60	0.54	0.28	2.62E−02	0.45	0.22	2.61E−04
rs932327	22	37905173	G	A	0.15	2.11	2.43E−05	0.47	2.51	0.30	1.93E−03	1.92	0.22	3.13E−03
rs11933913	4	169609033	G	A	0.17	2.10	2.45E−05	0.14	2.96	0.29	1.96E−04	1.72	0.22	1.33E−02
rs6438086	3	112359986	A	G	0.33	0.45	2.52E−05	0.46	0.37	0.33	2.46E−03	0.50	0.23	2.51E−03
rs77944815	4	141194295	T	C	0.08	2.53	2.59E−05	0.76	2.33	0.35	1.64E−02	2.67	0.28	5.24E−04
rs10917696	1	163149325	C	T	0.22	2.02	2.63E−05	0.57	1.77	0.29	4.64E−02	2.16	0.21	1.80E−04
rs72816289	5	163771489	G	A	0.07	2.83	2.67E−05	0.41	3.62	0.39	1.04E−03	2.40	0.32	6.02E−03
rs11903647	2	34027682	G	A	0.10	2.36	2.91E−05	0.87	2.47	0.35	8.78E−03	2.30	0.26	1.11E−03
rs6571194	6	96755269	C	T	0.28	0.42	3.03E−05	0.44	0.51	0.33	4.12E−02	0.37	0.27	1.99E−04
rs969663	13	69408347	C	T	0.46	1.89	3.12E−05	0.43	1.63	0.24	4.44E−02	2.08	0.20	1.92E−04
rs35752324	14	100134209	T	C	0.13	2.23	3.34E−05	0.99	2.24	0.34	1.89E−02	2.23	0.23	6.24E−04
rs71582000	7	128780057	G	A	0.08	2.51	3.59E−05	0.89	2.40	0.39	2.41E−02	2.57	0.27	5.30E−04
rs953226	9	129286868	A	C	0.08	2.41	4.13E−05	0.79	2.62	0.37	9.81E−03	2.32	0.26	1.40E−03
rs2292630	15	29429143	T	C	0.06	2.88	4.19E−05	0.88	2.72	0.46	2.92E−02	2.96	0.31	5.18E−04
rs11208611	1	65684425	T	C	0.32	1.92	4.22E−05	0.94	1.89	0.26	1.38E−02	1.94	0.20	1.07E−03
rs4745114	9	74304506	A	G	0.46	0.52	4.43E−05	0.44	0.44	0.27	2.09E−03	0.57	0.20	5.18E−03
rs5994697	22	33607304	A	C	0.33	0.47	4.54E−05	0.37	0.56	0.28	4.04E−02	0.40	0.25	2.74E−04
rs17380507	15	77235361	T	C	0.48	0.53	4.58E−05	0.87	0.54	0.25	1.53E−02	0.52	0.20	1.04E−03
rs75030100	1	73511653	T	G	0.07	2.63	4.75E−05	0.14	4.34	0.41	3.68E−04	2.05	0.29	1.37E−02
rs11825966	11	6734161	T	C	0.06	2.63	4.75E−05	0.73	2.35	0.41	3.90E−02	2.79	0.29	4.30E−04

Meta analyses of two genome‐wide association (GWA) analyses: the adult and the paediatric OLT cohort. Variants with both significant p‐value in adult and paediatric cohort (p < .05) are shown, and variants are sorted by p‐value (with the cut‐off value of 5 × 10⁻⁰⁵). The GWA results in adult and pediatric OLT cohort are reported by OR, SE and p‐value, respectively.

Abbreviations: CHR, chromosome; MAF, minor allele frequency; OR, odd ratio; POS, position per base‐pair; Q, p‐value for Cochrane's Q statistic; SE, standard error of OR; SNP, single‐nucleotide polymorphism.