FIGURE 3.

Utrophin A promoter transcriptional activation pathways. (A) Nucleotide sequence of the human UTRN gene promoter including the transcriptional regulatory elements: NFAT binding site, PPRE site, Jazz binding site, E‐box site, N‐box site and Sp binding sites. The arrow indicates the transcription starting site. (B) Representation of the utrophin A promoter regulatory binding sites, their transcriptional upregulation mechanisms and the compounds involved in utrophin upregulation through these signalling pathways (in blue). The compounds that act through promotion of the slow and oxidative phenotype are included in the purple box. Created with BioRender.com