. 2021 Feb 13;10(10):1242–1247. doi: 10.1002/cpdd.920

Table 1.

C_ave, C_max, C_last, AUC_last (Arithmetic Mean ± Standard Deviation) and t_max Values for Orlistat (Median and Interquartile Range) Determined at Day 1 (Visit 2) and Day 14 (Visit 4), Respectively, During the 14‐Day Study

Treatment Group Orlistat/Acarbose, mg	Group I MR‐OA 60/20 (n = 17)	Group II MR‐OA 90/30 (n = 17)	Group III MR‐OA 120/40 (n = 16)	Group IV Conventional Orlistat 120 (n = 17)
C_ave, ng/mL‐V 2	0.38 ± 0.32 ^a	0.64 ± 0.63 ^a	0.53 ± 0.35 ^a	1.21 ± 0.67
C_ave, ng/mL‐V 4	0.35 ± 0.21 ^a	0.60 ± 0.40 ^a	0.54 ± 0.35 ^a	1.45 ± 1.10
C_max, ngl/mL‐V 2	0.65 ± 0.57 ^a	1.26 ± 1.42 ^a	1.05 ± 0.87 ^a	3.32 ± 1.93
C_max, ng/mL‐V 4	0.88 ± 0.69 ^a	1.55 ± 1.13 ^a	1.24 ± 1.10 ^a	3.19 ± 2.28
C_last , ng/mL‐V 2	0.62 ± 0.59 ^a	1.24 ± 1.43 ^a	1.01 ± 0.87 ^a	2.86 ± 1.52
C_last, ng/mL‐V 4	0.80 ± 0.76 ^a	1.54 ± 1.14 ^a	1.24 ± 1.10 ^a	2.89 ± 1.99
AUC_last, ng/mL × h‐V 2	0.57 ± 0.46 ^a	1.27 ± 1.19 ^a	1.13 ± 1.05 ^a	3.42 ± 3.48
AUC_last, ng/mL × h‐V 4	0.95 ± 0.52 ^a	1.53 ± 1.10 ^a	1.51 ± 1.36 ^a	4.08 ± 3.78
t_max, h‐V 2	6.00 (5.88‐6.00)	6.00 (6.00‐6.00)	6.00 (6.00‐6.00)	6.00 (6.00‐6.00)
t_max, h‐V 4	6.00 (4.90‐6.00)	6.00 (6.00‐6.00)	6.00 (6.00‐6.00)	6.00 (6.00‐6.00)

AUC_last,: area under the concentration–time curve from time 0 to the last measurable concentration; C_ave, individual mean concentration; C_last, last measurable concentration; C_max, maximum plasma concentration; t_max, time to maximum plasma concentration.

^{^a}

Significantly different from conventional orlistat group, adjusted for multiple comparisons according to Holm.11 “V 2” = visit 2 (day 1), “V 4” = visit 4 (day 14).