FIGURE 4.

Decreased levels of Annexin A1 expression enhanced apoptosis induced by TPF chemotherapy in oral cancer cell lines. After transfection of HB96 cells with shRNA1 (A) and shRNA2 (B), the expression levels of cleaved PARP and cleaved caspase 3 were increased significantly following treatment of the cells with docetaxel (5 nM), cisplatin (2 µg/ml) and 5‐fluorouracil (2 µg/ml) for 72 hr. After transfection of HN4 cells with shRNA1 (C) and shRNA2 (D), the expression of cleaved PARP and cleaved caspase 3 was increased significantly in cells treated with docetaxel (5 nM), cisplatin (2 µg/ml) and 5‐fluorouracil (2 µg/ml) for 72 hr; a similar response was also noted in CAL27 cells