Figure 3.

Plasma concentration profiles of unchanged edaravone over time after multiple administrations of edaravone in groups 1 and 2 of cohort 1 in study 2. In group 1, edaravone was administered once daily for 8 days from days 6 to 13 with coadministration of 10 mg of rosuvastatin on day 9 (fourth edaravone dosing) and 50 mg of sildenafil on day 12 (seventh edaravone dosing). In group 2, edaravone was administered once daily for 5 days from days 3 to 7 with coadministration of 40 mg of furosemide on day 6 (fourth edaravone dosing). ^aOne subject withdrew from the study before the administration of sildenafil and edaravone.