Figure 5.

a) Time‐dependent rheology shows self‐regulating behavior of the supramolecular hydrogel in the presence of d‐glucose. The measurement starts with a gel containing enzymes HRP and GOx with introduction of d‐glucose. G′ and G′′ were measured after every 30 min for 20 h. The gel first transformed into sol changing G′ from ca. 100 Pa to 23 Pa due to oxidation of Fc to Fc⁺ over time. At this point, 0.66 m glucose was added again to run another cycle of gel‐sol‐gel transition. The sol returned to gel (Fc⁺ reduced to Fc), which eventually transferred into sol (Fc oxidized to Fc⁺) by a feedback in the network (autonomous production of H₂O₂) and showed a reversible transition between the two states with constant supply of d‐glucose to the system. b) Carboxyfluorescein dye release showing sensitivity of hydrogel towards d‐glucose (0.66 m) compared to a control hydrogel.