Disposition of the study patients. A total of 444 participants were screened, and 401 were enrolled. One patient was determined not to have polyarticular juvenile idiopathic arthritis (JIA) and was excluded from the analysis. Of the 400 analyzable participants at baseline, 257 (64%) were started on the step‐up consensus treatment plan (CTP), 100 (25%) on the early combination CTP, and 43 (11%) on the biologic first CTP. Eighteen participants were lost to follow‐up: 2 withdrew consent and 16 moved to a non‐participating clinical site. Of the patients lost to follow‐up, 2 patients were lost to follow‐up after the baseline visit, 2 patients after the 3 month visit, 2 patients after the 6 month visit, and 12 patients after the 9 month visit, leaving 382 participants with at least 12 months of follow‐up data available (250 in the step‐up CTP group, 94 in the early combination CTP group, and 38 in the biologic first CTP group). Of these 382 participants, 44 missed the 12‐month primary end point visit, leaving a total of 338 evaluable CTP participants for the primary end point (222 in the step‐up CTP group, 81 in the early combination CTP group, and 35 in the biologic first CTP group). CID = clinically inactive disease.