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. 2021 Jul 26;16(19):3083–3093. doi: 10.1002/cmdc.202100396

Scheme 1.

Scheme 1

Reagents and conditions: i) acyl chloride derivatives, DIPEA, DCM, 5 h, rt; ii) carboxylic acid derivatives, HBTU, TEA, DMF, MW: 10 min, 50 °C, 200 W; iii) Hydrazine, Pd/C, EtOH, reflux, 2 h.