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. 2021 May 28;16(17):2650–2668. doi: 10.1002/cmdc.202100204

Figure 1.

Figure 1

(a) Biosynthesis of glutathione is dependent on the xCT antiporter, a function that is proven to be inhibited by sulfasalazine. (b) Glutathione operates as an antioxidant for ROS, scavenging free radical generated from oxidative stress as well as for free radical generated by γ‐irradiation during radio therapy.