Table 3.

Extraction recovery and matrix effect of eight TKIs.

Analyte	Nominal Concentration (nM)	Extraction Recovery (%) (n=3)	Matrix Effect (%) (n=3)
Erlotinib	400	87.6	96.6
	50	100.3	100.7
	6.25	91.6	110.7
Sorafenib	1600	106.5	110.1
	200	106.8	111.0
	25	105.2	118.9
Sunitinib	800	113.8	103.4
	100	104.6	97.4
	12.5	110.1	82.3
Dasatinib	1600	85.0	104.4
	200	96.2	102.1
	25	102.2	93.6
Lapatinib	1600	97.4	110.3
	200	100.1	105.1
	25	108.3	116.8
Nilotinib	1600	96.3	97.4
	200	108.3	114.1
	25	116.0	113.7
Pazopanib	800	101.1	85.1
	100	100.7	85.1
	12.5	93.8	82.9
Axitinib	800	102.0	92.1
	100	93.2	88.5
	12.5	88.2	90.8