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Pharmacokinetic parameters of sorafenib and pazopanib after oral administration of 1 mg/kg as a mixture of 11 TKIs in mice (n = 4).
| Analyte | Cmax (ng/ml) | Tmax (min) | AUC0-t (min ng/ml) |
|---|---|---|---|
|
| |||
| Sorafenib | 154.3 ± 30.4 | 60.0 ± 40.6 | 33489.4 ± 6766.4 |
| Pazopanib | 717.0 ± 205.5 | 97.5 ± 66.5 | 248812.5 ± 65971.3 |
