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. 2021 Jun 22;16(18):2786–2801. doi: 10.1002/cmdc.202100283

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© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Influence of L21 on the conversion of cYY to mycocyclosin by CYP121. CYP121 was incubated with L21, electron transfer system (Arh1, etp1fd), regenerative system (G6P‐DH, G6P, MgCl2) and substrate cYY. The conversion was stopped by the addition of MeOH with ISTD and analyzed via LC‐MS/MS. DMSO was used as control. A: time‐dependent concentration of cYY for different inhibitor concentrations. The relative inhibition was calculated via determination of the respective reaction velocity. IC50 values were determined through non‐linear regression of inhibition vs. log c (B). The error bars represent the standard deviation of at least 2 replicate measurements.