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. 2021 Jun 22;16(18):2786–2801. doi: 10.1002/cmdc.202100283

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© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect on intracellular replication in macrophages. Macrophages were infected with M. bovis BCG and maintained in the presence of selected CYP125 inhibitors C36 and C23, CYP121 inhibitors I:16, I:47 and I:48 or dual inhibitor C43. At 72 h post infection, macrophages were plated on agar to determine intracellular CFU. Penicillin‐Streptomycin and DMSO were used as positive and negative controls, respectively. Significance of results for treated versus untreated cells (DMSO). **p<0.001; ***p<0.0001.