Table 3.
Prediction: Complex β-lactamase backgrounds (IRT, ESBL, +/− KPC) test susceptible to CAZ/AVI.
| Result | ||||
|---|---|---|---|---|
| # of isolates | bla genes | PIP/TAZO | TOL/TAZO | CAZ/AVI |
| 3 | blaCTX-M-15, blaTEM-76 (S130G), & blaSHV-27 (G156D) | S | S | S |
| 1 | blaCTX-M-15, blaTEM-76 (S130G), & blaSHV-12 (L35Q/G238S/E240K) | I | R | S |
| 7 | blaCTX-M-15, blaTEM-30 (R244S), & blaSHV-5 (G238S/E240K) or blaSHV-27 | S ^ | S | S |
| 1 | blaCTX-M-15, blaTEM-33 (M69L), & blaSHV-27 | S | S | S |
| 11 | blaTEM-79 (R244G), blaSHV-5 or blaSHV-12, or blaSHV-27, & blaKPC-2 | R | R | S |
| 1 | blaTEM-30 (R244S), blaSHV-12, blaCTX-M-15, & blaKPC-2 | R | R | S |
^
(6 isolates S, 1 isolate R)