Table 2.
Meta analysis of the association of IL-10 -819C/T, -592A/C polymorphisms and PE susceptibility.
| Number | Study of association | Heterogeneity of study design | ||||||||
| Polymorphism studied | Ethnicity | Cases | Controls | OR | 95% CI | Z (P value) | P | I 2 | Model | |
| IL-10 -819 | C vs T | Overall | 1281 | 1771 | 1.188 | 0.958–1.472 | 1.57 (.116) | .001 | 69.10% | Random |
| African | 356 | 478 | 0.791 | 0.628–0.996 | 2.00 (.46) | .139 | 54.40% | Fixed | ||
| Caucasian | 385 | 695 | 1.270 | 1.024–1.576 | 2.17 (.039) | .313 | 13.90% | Fixed | ||
| Asian | 452 | 506 | 1.410 | 1.054–1.886 | 2.31 (.021) | .082 | 60.00% | Random | ||
| CC + CT vs TT (recessive) | Overall | 1281 | 1771 | 1.065 | 0.858–1.322 | 0.57 (.569) | .107 | 39.20% | Fixed | |
| African | 356 | 478 | 0.662 | 0.391–1.121 | 1.54 (.125) | .107 | 61.50% | Fixed | ||
| Caucasian | 385 | 695 | 1.046 | 0.581–1.883 | 0.15 (.880) | .702 | 0.00% | Fixed | ||
| Asian | 452 | 506 | 1.316 | 1.002–1.728 | 1.98 (.048) | .925 | 0.00% | Fixed | ||
| CC vs CT + TT (dominant) | Overall | 1281 | 1771 | 1.361 | 0.984–1.883 | 1.86 (.063) | <.001 | 72.90% | Random | |
| African | 356 | 478 | 0.774 | 0.576–1.041 | 1.69 (.091) | .408 | 0.00% | Fixed | ||
| Caucasian | 385 | 695 | 1.487 | 0.953–2.321 | 1.75 (.081) | .073 | 61.80% | Random | ||
| Asian | 452 | 506 | 1.770 | 0.948–3.303 | 1.79 (.073) | .017 | 75.40% | Random | ||
| CC vs. TT | Overall | 1281 | 1771 | 1.175 | 0.743–1.859 | 0.69 (.491) | .010 | 60.40% | Random | |
| African | 356 | 478 | 0.600 | 0.347–1.037 | 1.83 (.067) | .107 | 61.60% | Fixed | ||
| Caucasian | 385 | 695 | 1.188 | 0.645–2.189 | 0.55 (.58) | .858 | 0.00% | Fixed | ||
| Asian | 452 | 506 | 1.755 | 1.236–2.492 | 3.14 (.002) | .216 | 34.60% | Fixed | ||
| IL-10 -592 | A vs C | Overall | 1133 | 1238 | 0.786 | 0.617–1.001 | 1.95 (.051) | .001 | 73.30% | Random |
| Caucasian | 288 | 261 | 0.725 | 0.554–0.948 | 2.35 (.019) | .448 | 0.00% | Fixed | ||
| Asian | 417 | 582 | 0.635 | 0.530–0.762 | 4.88 (<.001) | .862 | 0.00% | Fixed | ||
| AA vs AC + CC (recessive) | Overall | 1133 | 1238 | 0.855 | 0.537–1.361 | 0.66 (.508) | .001 | 72.70% | Random | |
| Caucasian | 288 | 261 | 1.170 | 0.585–2.338 | 0.44 (.658) | .242 | 27.00% | Fixed | ||
| Asian | 417 | 582 | 0.536 | 0.408–0.703 | 4.50 (<.001) | .427 | 0.00% | Fixed | ||
| AA + AC vs CC (dominant) | Overall | 1133 | 1238 | 0.716 | 0.526–0.975 | 2.12 (.034) | .010 | 64.10% | Random | |
| Caucasian | 288 | 261 | 0.700 | 0.404–0.804 | 3.21 (.001) | .233 | 29.80% | Fixed | ||
| Asian | 417 | 582 | 0.609 | 0.444–0.836 | 3.07 (.002) | .638 | 0.00% | Fixed | ||
| AA vs CC | Overall | 1133 | 1238 | 0.784 | 0.459–1.341 | 0.89 (.374) | .002 | 70.90% | Random | |
| Caucasian | 288 | 261 | 0.952 | 0.463–1.959 | 0.13 (.894) | .342 | 0.00% | Fixed | ||
| Asian | 417 | 582 | 0.441 | 0.308–0.633 | 4.45 (<.001) | .935 | 0.00% | Fixed | ||