TABLE 3.

Downregulated KEGG pathways in PMNs isolated from young WT or CD73KO mice in response to S. pneumoniae infection^a

KEGG pathway term	Downregulation in:
	Young WT PMNs upon S. pneumoniae challenge			CD73KO PMNs upon S. pneumoniae challenge
	No. of genes	Genes	P value	No. of genes	Genes	P value
Auto-immune thyroid disorder	3	CTLA4, GZMB, IL10	1.70E−02	3	GZMB, CD40, IL10	3.1E−02
Cytokine-cytokine receptor interaction	4	CCR7, CXCL16, TNFRSF8, IL10	3.0E−02	6	CCR7, CCL2, CXCR5, CXCL16, CD40, IL10	2.20E−03
Malaria				4	ICAM1, CCL2, CD40, IL10	8.20E−04
Chemokine signaling pathway				5	ITK, CCR7, CCL2, CXCR5, CXCL16	6.7E−03
Allograft rejection				3	GZMB, CD40, IL10	2.0E−02
Cell adhesion molecules (CAMs)				4	PVR, ICAM1, CD40, SDC4	2.5E−02

^aSignificantly (P ≤ 0.05) downregulated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways with genes involved and P values based upon DAVID analysis of significantly downregulated differentially expressed genes (DEGs) (log₂FC ≥ 1.0; FDR < 0.05), compared to mock-challenged controls, in PMNs isolated from young WT or CD73KO mice in response to S. pneumoniae TIGR4 infection.