TABLE 1.
Preerythrocytic vaccine candidates selected for sterile protection analysis
| P. yoelii orthologue (PlasmoDB identification no.)a | Protein name | Protein function | P. yoelii amino acid positions in vaccine | Predicted size (kDa) | Type of recombinant protein |
|---|---|---|---|---|---|
| PY03000 (Pf3D7_0730200) | AP-4 complex subunit β, putative | 6–891 | 104 | Insect cell expression | |
| PY00162/Pb103100 (Pf3D7_1411500) | MIF4G | Conserved Plasmodium protein, unknown function (MIF4G domain) | 3–980 | 117 | Insect cell expression for P. yoelii; in vivo expression by GG-delivered plasmid for P. berghei |
| PY04499 (Pf3D7_1418100) | LISP1 | LS egress | 1172–1732 | 66 | Insect cell expression |
| PY04162 (Pf3D7_1207400) | Conserved Plasmodium protein, unknown function | 1–387 | 46 | Insect cell expression | |
| PY01495 (Pf3D7_1241500) | Conserved Plasmodium protein, unknown function | 1–467 | 55 | E. coli expression | |
| PY03269/Pb090210 (PF3D7_1147000) | SLARP | LS development and transmission regulator | 1356–1989 | 74 | E. coli expression for P. yoelii; in vivo expression by GG-delivered plasmid for P. berghei |
| PY00669/Pb131980 (PF3D7_1456100) | SHMT | Serine hydroxymethyltransferase, putative | 1–484 | 57 | Insect cell expression for P. yoelii; in vivo expression by GG-delivered plasmid for P. berghei |
| PY00712 (Pf3D7_0506200) | TBP | Transcription initiation factor | 1–277 | 33 | E. coli expression |