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. 2021 Oct 1;12:763313. doi: 10.3389/fimmu.2021.763313

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Copyright © 2021 Roy, Sharma, Wasson, Jain, Hassan and Prakash

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-coding RNAs regulates macrophage plasticity during the pathogenesis of Covid 19 disease. 1. N/S/G spike proteins bind to ACE2 receptors on lung cells and determine the entry of the SARS-CoV-2 virus. 2. miRNA can be direct targets since they can regulate the expression of ACE2 in various organs. 3. Infection produces an copius amount of IL-6, which drives the fate of CD14 monocytes/macrophages towards M2 phenotype via MAPK signaling, which promotes viral replication. 4. In view of this virus eliminating inflammatory niche could be achievd by promting M1 phenotype in TLR depenedent MYD88/ERK/NF-Kb pathway. 5. This could be fosterd by application of MAPK inhibitors like simvastatin in conjuction of TLR antagonist which can help immune cells to curb SARS-CoV-2 in the host effectively.