. Author manuscript; available in PMC: 2021 Oct 15.

Published in final edited form as: Ophthalmology. 2016 Aug 29;123(10):2085–2092. doi: 10.1016/j.ophtha.2016.06.038

Table 4.

Change in intraocular pressure.

Change in IOP (mm Hg)
		9:30 AM	10:30 AM	11:30 AM	12:30 PM	1:30 PM	2:30 PM	3:30 PM
Latanoprost Solution
Treatment	Day 3		−5.4 ± 1.0
	Day 5	−3.4 ± 0.3	−5.3 ± 0.5	−6.6 ± 1.3	−5.4 ± 1.0^*	−5.1 ± 1.4	−4.0 ± 0.6	−2.9 ± 1.0
Post-treatment	Day 3		−0.6 ± 1.4
CL_LO Treatment	Day 3		−6.3 ± 1.0^*
	Day 5						−6.7 ± 0.3 ^§ (n=3)
	Day 8	−7.8 ± 3.8^*	−7.4 ± 3.4^*	−7.8 ± 3.0^*	−6.9 ± 1.3^*	−6.6 ± 2.1	−5.3 ± 1.7	−4.0 ± 1.1
Post-Treatment	Day 1		−3.0 ± 3.4
Post-Treatment	Day 3						−1.8 ± 3.9
CL_HI Treatment	Day 3		−10.5 ± 1.4^**^§
	Day 5						−11.1 ± 4.0^*^§
	Day 8	−10.0 ± 2.5^* ^§ (n = 3)	−9.3 ± 4.2^* (n=3)	−8.8 ± 3.5^** (n=3)	−9.2 ± 3.2^* (n=3)	−10.2 ± 2.4^*^§ (n=3)	−8.2 ± 2.3 ^*^§ (n=3)	−6.0 ± 4.4 (n=3)
Post-Treatment	Day 1		−4.0 ± 3.1 (n=3)
Post-Treatment	Day 3						−3.7 ± 4.0 (n=3)
Post-T reatment	Day 8		−1.0 ± 1.3 (n=3)

Data are mean changes in Intraocular pressure (IOP) ± standard deviation from baseline

p<0.05

^**

p<0.005 in comparison to baseline (2-tailed Student-test);

^§

p<0.05 in comparison to latanoprost drop treatment at the same time, using Student t-test. Changes in IOP for the CL_HI on Day 8 were compared to the last day of treatment (Day 5) with latanoprost drops. CL_LO = Low-dose contact lens. CL_HI = High-dose CL; n = 4 unless otherwise noted.