Table 2.

The Mixed Effect Model Analysis of Primary Outcome Measures

	Group	Age	Gender	Time	Comorbidity	Age Group*	Gender Group*	Time Group *	Comorbidity Group*
PSQI
F	2.129	20.486	0.031	71.178	0.261	0.832	1.406	4.756	1.058
P	0.145	<0.001	0.860	<0.001	0.609	0.362	0.236	0.004	0.304
ISI
F	0.440	4.222	6.264	59.901	0.005	0.038	1.682	4.130	0.534
P	0.507	0.040	0.012	<0.001	0.946	0.845	0.195	0.008	0.465

Notes: Data were analyzed using a mixed-effect model for repeated measures (MMRM). *Interaction.

Abbreviations: PSQI, Pittsburgh sleep quality index; ISI, insomnia severity index.