Table 1.

Variables Included in the Univariate and Multivariate Survival Models Grouped Based on Function in the Core Signaling Pathways

Variable	Mutations/Alterations
MDM/TP53	MDM2, MDM4 or TP53 mutations
CDKN2A/B	CDKN2A/B/C deletions or mutations (rare)
CDK/CCND	CDK4/CDK6 amplifications, or CCND1/CCND2 amplifications
RB1	RB1 mutations/deletions
EGFR/ERBB	EGFR amplifications/mutations or ERBB (2-4) mutations.
FGFR	FGFR mutations/amplifications
PDGFRA/KIT	PDGFRA mutations/amplifications
NF1	NF1 mutations
PTEN	PTEN mutations/deletions
PIK3R1	PIK3R1 mutations/deletions
PI3K gain	PIK3CA mutations, mTOR mutations or AKT amplifications
MYC	MYC: MYC/MYCN amplifications
TERT	TERT promoter mutations