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(A) PCA clustering showed that DND1 KO lines clustered together with DND1 WT lines. Main differences are associated with the differentiation status, with PGCLCs clustering distinct from iPSCs and iMeLCs. (B) Heatmap showing differentially expressed genes in PGCLCs. DND1 KO PGCLCs show decreased expression in known PGC differentiation regulators as PRDM1 and NANOS3 (cluster 1).
