Table 5.
Sensitivity analysis: estimated risk of breast cancer associated with global sleep index (GSI), estimated by multivariable logistic regression, applying various exclusions.
| Study Population | Adjusted Odds Ratios (95% CI)a
Global Sleep Index (GSI) |
|||
|---|---|---|---|---|
| 1st Quartile (better sleep) | 2nd Quartile | 3rd Quartile | 4th Quartile (worse sleep) | |
| Full Study Population (n=41,505) | 1.00 | 1.02 (0.92, 1.14) | 1.18 (1.05, 1.32) | 1.24 (1.12, 1.38) |
| Excluding 363 cases diagnosed within 2 years of Q5 fill date | 1.00 | 0.98 (0.88, 1.11) | 1.13 (1.00, 1.27) | 1.20 (1.07, 1.34) |
| Excluding 178 cases diagnosed within 1 year of Q5 fill date | 1.00 | 1.00 (0.89, 1.12) | 1.15 (1.02, 1.29) | 1.20 (1.08, 1.34) |
| Restricted to those with no recent changes in sleepb (n=36,542) | 1.00 | 1.02 (0.91, 1.14) | 1.17 (1.03,1.31) | 1.16 (1.04,1.30) |
| Restricted to those who report long-term sleep stabilityc (=28,714) | 1.00 | 1.03 (0.91, 1.17) | 1.23 (1.08,1.41) | 1.16 (1.02,1.32) |
a
Adjusted for age at Q5, race (white/non-white), total pack-years of smoking, age at first full-term pregnancy, BMI at Q5, physical activity at Q5, family history of breast cancer through Q4, age at menopause (calculated at Q5), medication use for depression at Q5, NSAID use at Q5, and marital status at Q5.
b
Reported sleep habits were typical of the prior year.
c
Reported sleep habits were typical of at least the prior 5 years.