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. 2021 Oct 15;7(42):eabh1434. doi: 10.1126/sciadv.abh1434

Fig. 4. The miR-1/V-ATPase functional interaction is conserved in Drosophila.

Fig. 4.

(A) Reduction in VHA100-3 or VHA44 levels, but not of VHA55 or VHA68-2, rescues Dmir-1(0) morphological defects. Top: Representative pictures of 24-hour posthatching larvae are shown. Scale bars, 200 μm. Bottom: Quantification of whole-body length. n represents number of animals analyzed. P values by Kruskal-Wallis test are indicated. (B) Reduction in VHA100-3 or VHA44 levels prolongs Dmir-1(0) life. Curves and error bars represent the average and SD of three independent biological replicates, consisting of 10 Drosophila larvae each. (C) Muscle-specific overexpression of VHA100-1 causes larval lethality 2 days after hatching. Curves and error bars represent the average and SD of three independent biological replicates, consisting of five to eight Drosophila larvae each. Representative pictures of larvae 24 hours after hatching are shown. Scale bars, 200 μm.