Figure 1.

Proposed models for glutaminolytic control of radiation-induced DNArepair and survival. Glutaminase can be inhibited physiologically following DNAdamage by Sirtuin 4 thus inhibiting proliferation and avoiding genomicinstability, whereas small molecule inhibition of Glutaminase can impactanti-oxidantdefences and radiosensitize. Conversion of glutamate to glutamineby Glutaminase is associated with radiation resistance. Blockade of glutamineuptake by membrane transporters may affect multiple fates of intracellularglutamine with diverse biological outcomes