Table 4.

Neoadjuvant chemotherapy response correlation with DCE-MRI parameters in hypopharyngeal cancer

Group		Parameters
	Ktrans (/min）	Kep (/min）	Ve
Responders(n = 30)	0.179 ± 0.055	0.291 ± 0.076	0.663 ± 0.314
Non-responders(n = 16)	0.147 ± 0.030	0.267 ± 0.081	0.610 ± 0.250
t	2.131	0.962	0.585
P	0.039	0.341	0.562
Pretreatment(n = 46)	0.232 ± 0.072	0.368 ± 0.089	0.660 ± 0.264
Post-treatment(n = 46)	0.168 ± 0.050	0.282 ± 0.077	0.645 ± 0.291
t	7.952	9.202	0.433
P	0.000	0.000	0.667

K_ep, the rate transferconstant of the contrast agent from EES to VS; K_trans, the volume transfer constant of the contrast agent fromVascular space (VS) to Extra-vascular extracellularspace (EES); V_e, the volume of EES per unitvolume of the contrast agent in the tissue.

p-value for the comparison of DCE-MRI valueswas calculated using unpaired Student’s t test or paired Student’s t test.