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. 2021 Nov 11;184(23):5699–5714.e11. doi: 10.1016/j.cell.2021.10.011

Figure S2.

Figure S2

Effect of vaccine dosing interval and MSD sensitivity threshold on IgG responses, related to Figures 2B and 3C

A. Effect of a dosing interval grouped 4 weekly on SARS-CoV-2 S-specific IgG responses in naive (gray symbols) and pre-infected individuals (red symbols). IgG responses were measured in serum 4weeks after the second dose using multiplexed MSD immunoassays and are shown in Arbitrary Units/ml (AU/ml). Bars represent the median with interquartile range. Unpaired comparisons between the groups were performed using a Mann-Whitney test.

B. Effect of a short or a long vaccine dosing interval on SARS-CoV-2 S-, RBD- and N-specific IgG responses in naive (gray symbols) and pre-infected individuals (red symbols) after removing participants with IgG N responses above the sensitivity threshold (3,874 AU/ml). IgG responses were measured in serum 4 weeks following the second dose using multiplexed MSD immunoassays and are shown in Arbitrary Units/ml (AU/ml). Bars represent the median with interquartile range. Unpaired comparisons between the groups were performed using a Mann-Whitney test. Horizontal dotted lines represent the sensitivity threshold of each assay based on pre-pandemic sera.