Table 2.

Linear mixed-effects regression models of T cell (IFNγ) or Ab (IgG) immune responses

	S T cell responses in naive participants			S T cell responses in pre inf participants			S Ab responses in naive participants			S Ab responses in pre inf participants
Coefficient	Estimates	CI (95%)	p Value	Estimates	CI (95%)	p Value	Estimates	CI (95%)	p Value	Estimates		CI (95%)		p Value
Intercept	1.47	0.95–1.98	<0.001a	1.92	1.26–2.59	<0.001a	4.84	4.42–5.26	<0.001a	5.77		5.41–6.12		<0.001a
Age	−0.00	−0.02 to 0.01	0.705	0.01	−0.01 to 0.02	0.480	−0.01	−0.02 to 0.00	0.090	−0.00		−0.01 to 0.01		0.640
Sex (M)	−0.15	−0.54 to 0.23	0.435	0.42	0.01–0.84	0.046a	0.09	−0.26 to 0.45	0.608	−0.04		0.29 to 0.21		0.757
Time point (pre vaccine)	−0.79	−1.08 to −0.50	<0.001a	−0.88	−1.09 to −0.67	<0.001a	−2.79	−2.95 to −2.63	<0.001a	−1.65		−1.77 to −1.54		<0.001a
Time point (dose 1 + 10 weeks)	0.28	−0.01 to 0.57	0.060	0.08	−0.13 to 0.28	0.466	−0.38	−0.53 to −0.22	< 0.001a	−0.18		−0.29 to −0.07		0.002a
Time point (dose 2 + 4 weeks)	0.85	0.56–1.13	<0.001a	0.31	0.10–0.51	0.003a	0.97	0.81–1.12	<0.001a	−0.02		−0.13 to 0.10		0.793
Random effects
σ2	0.28			0.14			0.09			0.05
τ00	0.06 PubID			0.12 PubID			0.09 PubID			0.04 PubID
ICC	0.18			0.46			0.49			0.43
N	26 PubID			26 PubID			29 PubID			29 PubID
Observations	103			104			116			116
Marginal R2/conditional R2	0.506/0.593			0.462/0.710			0.914/0.956			0.848/0.913

Shown are four linear mixed-effect regression models (LMERs) of T cell or Ab responses in naive or pre-inf individuals across vaccine time points in the long vaccine dose regimen. Variables include age, sex, and time point. Variable references are sex (F [female] versus M [male]), time point (dose 1 + 4 weeks versus pre-vaccine/dose 1 + 10 weeks/dose 2 + 4 weeks.

^aIndicates statistical significance.