Table 3.

Generalized linear regression models of T cell (IFNγ) or antibody (IgG) immune responses

	S T cell responses in naive and pre inf participants at dose 2 + 4 weeks			S Ab responses in naive participants at dose 2 + 4 weeks			S Ab responses in pre inf participants at dose 2 + 4 weeks
Coefficient	Estimates	CI (95%)	p Value	Estimates	CI (95%)	p Value	Estimates	CI (95%)	p Value
Intercept	2.21	1.90–2.51	<0.001a	5.40	5.18–5.63	<0.001a	5.50	5.26–5.73	<0.001a
Age	−0.00	−0.01 to 0.00	0.522	−0.01	−0.01 to −0.00	0.020a	0.00	−0.00 to 0.00	0.554
Sex (M)	−0.06	−0.21 to 0.08	0.404	−0.10	−0.20 to 0.00	0.060	0.02	−0.09 to 0.13	0.690
Pre inf (yes)	0.38	0.24–0.51	<0.001a
Vaccine dose interval (long)	−0.19	−0.37 to −0.01	0.041a	0.20	0.08–0.32	0.001a	0.01	−0.14 to 0.17	0.886
Observations (R2)	374 (0.086)			189 (0.131)			184 (0.003)

Shown are three generalized linear models (GLMs) of T cell (naive and pre inf individuals), Ab (naive individuals), and Ab (pre inf individuals) responses 4 weeks after the second dose. Variables include age, sex, previous infection, and vaccine dose interval. Variable references are sex (F [female] versus M [male]), previous infection (yes versus no), and vaccine dose interval (short versus long). CI, confidence interval.

^aIndicates statistical significance.