Figure 7.

Passive transfer of IgG22 protects mice from lethal SARS-CoV-2 challenge

(A) BALB/c mice (N = 10/group) were treated with 20 mg/kg of mAb G4 (green), 20 mg/kg of IgG22 (blue), or 2 mg/kg (light blue) intraperitoneally on the day before challenge.

(B) Following challenge, mice were monitored for weight loss.The mean of each group is represented by a circle, error bars represent SEM.

(C–E) On day 4 post-challenge, lungs were harvested for analysis of tissue discoloration (C) and viral titers (D). Nasal turbinates were harvested for analysis of viral titers (E). Each circle represents an individual mouse. Box and whisker plots are shown. Boxes and horizontal bars denote the interquartile range (IQR) and medians, respectively; whisker end points are equal to the maximum and minimum values. Dotted lines represent lower limit of detection.

In (B), experimental groups were compared to the PBS control group at each day post-challenge by one-way ANOVA with Kruskal-Wallis post test. In (C) to (E), groups were compared to the PBS control by one-way ANOVA with Kruskal-Wallis post-test. = ^∗p < 0.05, ^∗∗p < 0.01.

See Figure S7.